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Irritation
of the scalp causes hyperproliferation of keratinocytes (skin
cells).
This decreases the time taken for the keratinocytes to travel
between the basal layer (where they are formed) and the stratum
corneum (the outermost layers of skin), where they become
corneocytes.
The resulting corneocytes are not fully formed and are shed
in clumps (dandruff), pushed out by further keratinocytes making
their way to the surface.
This whole process compromises the barrier function of the skin
cells, allowing moisture to escape the skin and bacteria to be
introduced.
The perturbations in the epidermal barrier not only cause further
irritation and dandruff, but can also activate certain skin diseases,
like psoriasis.

The corneocytes shown here are not fully formed, allowing moisture
to be released through the scalp causing mass skin cell shedding
(dandruff) and leaving the skin susceptible to bacteria. |
At 0.5%, the Nanogen Onescalp active stimulates the synthesis of involucrin,
a terminal marker of keratinocyte differentiation.
It has been shown to stimulate the formation of the corneal
envelope, strengthening and protecting the barriers of the skin.

Nanogen Onescalp (0.5% active) stimulates the synthesis of involucrin,
shown in these pictures, the more active the synthesis, the more
flourescent it becomes.
Involucrin is responsible for the terminal phase of keratinocyte
differentiation, thereby ensuring the regulation of the formation
of the barrier function, shown below.

The corneocytes shown here are fully formed, locking the moisture
into the scalp and protecting it from dryness (dandruff), bacteria
introduction and skin diseases. |